Medical Met Mat

ORTOMAG

Specific objectives:

• Design, production and testing of biodegradable alloys from Mg-Ca-Zr, Mg-Ca-Y, Mg-Ca-Mn, Mg-Ca-Gd systems with applications in medical implantology;
• Employing 3 young researchers with full time (TUIASI, USAMV si INCDFT-IFT IAȘI);
• In vitro and in vivo biocompatibility testing in animal models for the classification of alloys used as biodegradable materials usable in medical implantology;
• Support the technological transfer of the results obtained at regional and national level to the economic and medical environment in Romania;
• Identifying an optimal, complex formula, made up of all six elements, as an ideal material for orthopedic implants.

Results:

• Designing, obtaining and testing 4 classes of biodegradable materials: Mg-Ca-Zr, Mg-Ca-Y, Mg-Ca-Mn, Mg-Ca-Gd, with 5 different concentrations;
• Determination of microstructural, mechanical, electrochemical, in vitro and in vivo properties of biodegradable alloys;
• Identifying an optimal concentration with specific concentration for medical applications in orthopedics;
• Dissemination of results through participation in national and international conferences;
• Publication of at least 6 ISI / BDI scientific articles and 4 patent applications patent applications;
• Organization of internships with students, master students, PhD students at specialized companies;
• Organization of meetings with economic agents / partners for the preparation of technological transfer to industrial beneficiaries.

BioTIT

Specific objectives:

• Designing, obtaining and testing of Ti-Mo-Si type alloys for medical applications, with the ultimate goal of promoting a new generation of titanium alloys;
• Employing 2 young researchers with full time (TUIASI și INCDFT-IFT IAȘI);
• In vitro biocompatibility study, implantation, osteointegration study, and resorption rate on animal experimental model;
• Testing and complete characterization of biomaterials obtained for patenting;
• Dissemination of results, attracting the interest of implant manufacturers to create medical devices from the new alloy system.

Results:

• Obtaining and structural characterization of at least eight Ti-based alloys with Mo and Si alloys with medical applications;
• Determination of functional properties and biocompatibility in vitro and in vivo of orthopedic alloys in the Ti-Mo-Si system;
• Evaluation of experimental results on the Ti-Mo-Si alloy system;
• Identifying an optimal Ti-Mo-Si ideal composition for orthopedic implants and identifying a global composition of the Ti-Mo-Zr-Ta-Si complex system;
• Publication of at least 6 articles in ISI-indexed journals, development of at least two new patents and participation in international exhibitions, fairs and salons of research.

The proposed alloys are new in the field, not reported to the research of the desired composition. The role of these alloy recipes is to improve the modulus of elasticity and mechanical strength without affecting the biological capabilities of the alloy as well as lowering the production price.

BIODENTRUT

Specific objectives:

• Design, production and testing of Co-Cr-MP alloys (MP = Ru, In, Pt, Au) with improved functional properties by coatings of carbonitrile thin films of transition metals usable in dental prostheses for metallic prostheses -ceramice.
• Employing 6 young researchers with full time (UPB, USAMV IAȘI and INOE 2000).
• In vitro and in vivo biocompatibility testing on animal models to classify alloys obtained as biomaterials usable in dentistry.
• Developing practical skills in obtaining and testing new biocompatible dental alloys.
• Ensuring the technological transfer of the results obtained at regional and national level.

Results:

• Obtaining and structural characterization of new types of dental alloys in the Co-Cr-MP system (Ru, In, Pt, Au) with applications in dentistry for metal-ceramic prosthetic works;
• Determination of functional properties and in vitro and in vivo biocompatibility testing of Co-Cr-MP system dental alloys;
• Identifying an ideal optimal composition for Co-Cr-MP dental alloys;
• Improving the biocompatibility of Co-Cr-MP alloys by coating them with biocompatible thin layers of carbonitrides of transition metals;
• Validation of Co-Cr-MP alloys covered / uncovered by testing them on animal model;
• Expertise of technologies and preparation of technological transfer to industrial beneficiaries;
• Scientific papers (6); patent applications (4); participation in international conferences.

HEAMED

Specific objectives:

• Design of CrFeMoNbTaTiZr alloy recipes from extremely low biotoxic chemicals used for medical device manufacturing;
• Employing 3 young researchers with full time (UPB and INOE 2000)
• Obtaining high biocompatible entropy alloys from the CrFeMoNbTaTiZr system for medical applications;
• Functioning technology of their surfaces by inoculation of hydroxyapatite doped with Ag, Cu or Zn, in order to increase the capacity of oseointegration.

Results:

• Recipes of high entropy alloys with biocompatible CrFeMoNbTaTiZr system ;
• Component Selection Algorithm for New Biocompatible Alloys;
• Documentation of alloys;
• Metalographic and mechanical characterization of biocompatible alloys;
• Patent applications;
• Inventory fair participations.

SOLION

Specific objectives:

• The study of saline aerosols in the enhancement of biocompatibility and osteointegration of metallic implants on which various depositions of nanostructures with continuous, uniform and cross-linked nanostructures were obtained by various methods (immersion, chemical interaction, electrodeposition, cathodic arc evaporation) , carbon nanocomposites (binary, ternary or quaternary carbon based nanocomposites), osteoconductive osteoconductive (HAp) layers doped with Ag and / or Mg by electrochemical techniques, chitosan, fibrin, collagen and serine, chemically modified.

Results:

• Elaboration of scientific papers, studies and dissemination at the highest international level (impact journals and conferences, international exhibitions, fairs and exhibitions - at least 6 ISI papers, 2 international scientific events, 2 exhibitions);
• Elaboration of at least 2 patent applications (new aerosol systems, obtaining new deposits, new methods of determination and measurement).